Hepatocyte Growth Factor (HGF) – a paracrine protein encoded by the gene HGF. Heterodimer consisting of α and β chains. Protease activity is not present and is activated by cleavage of the polypeptide chain into the α-chain and β-chain (encoding proteins 69 kDa and 34 kDa, respectively). Once synthesized as a precursor containing 104 amino acids, it can be transformed into 11 other types of active proteins, which have a variety of functions. Hepatocyte Growth Factor (HGF) is a paracrine protein that works to aid the process of blood vessel formation and organ regeneration. HGF is mainly produced in bone marrow and fibroblast cells. The presence of HGF is crucial for the development of embryonic stages such as liver development and cellular proliferation. HGF also keeps healing wounds from becoming clogged with scar tissue, allowing for quicker recoveries.
What is hgf: Hepatocyte Growth Factor (HGF) is a paracrine protein encoded by the HGF gene. HGF gene is present on chromosome 7. HGF is motility, cellular growth, and morphogenic factor. Even though HGF is a part of the plasminogen subfamily of S1 peptidase, it does not have any protease activity. HGF is a single inactive polypeptide, and serine proteases cleave it into a 69-kilodalton α-chain and 34-kilodalton β-chain. A disulfide bond formed between the αβ-chain creates an active heterodimeric protein.
What is granulocyte colony stimulating factor: G-CSF is a glycoprotein belonging to the Colony-Stimulating Factor family and produced mainly by macrophages and endothelium cells in response to an infectious disease or tissue damage. G-CSF binds with its cognate receptor (commonly known as CSF3R) on hematopoietic progenitor cells, which stimulates proliferation and differentiation into mature erythrocytes, granulocytes, and megakaryocytes. The protein has been implicated in various physiological processes such as the development of cells destined to form blood or lymphatic tissues, consolidation of bone marrow grafts, or for hematopoietic recovery in patients treated with chemotherapy.
G-CSF also known as colony stimulating factor 3 or CSF3 is a glycoprotein molecular weight 30 kDa. It is active in several cells: epidermal progenitor cells, fibroblasts and endothelial cells. Using the recombinant G-CSF protein can be used for treatment in certain acute hematological malignancies (such as AML), bone marrow failure syndrome, aplastic anemia, neutropenia associated with chemotherapy, graft vs. host disease and in some cases, thrombocytopenia.
Granulate Colony Stimulation Factor (G-CSF or GSCF) or Colony Stimulating Factor 3 (CSF 3) is a glycoprotein with distinct roles in the physiological and pathological condition. It stimulates the bone marrow to produce granulocytes and stem cells to release them into the bloodstream. G-CSF production typically indicates an endogenous presence of infection or tissue damage, stimulating the generation of G-CSF protein.
Granulate Colony Stimulating Factor is a protein that originates in bone marrow. Granulate Colony Stimulating Factor stimulates the bone marrow to produce granulocytes and stem cells to release them into the bloodstream. G-CSF production typically indicates Visit Your URL an endogenous presence of infection or trauma, where G-CSF can assist in fighting infection or preventing tissue damage. When searching for ‘Granulate Colony Stimulation Factor’ or ‘what is Granulate Colony Stimulation Factor’ one might hear people also refer to it as Coupled Signal Transduction Effector 17 (C17orf33), Colony Stimulating Factor 3 (CSF3OS), Granulocyte Colony Stimulating Factor (G-CSF), or C17orf33.